Endocrine Abstracts

Malignant transformation of the thyroid follicular cell in nodular goiter (NG) can lead to development of follicular adenoma (FA) or progression into: papillary thyroid carcinoma (PTC) or thyroid follicular cancer (FTC). Distinguishing follicular cell-derived thyroid tumors (FCDT) from NG on the molecular level can be especially helpful for underdetermined cytology (Bethesda III–IV) or FNAB with ‘follicular neoplasm’.Aim: Comparison of exp...

The genetic instability, i.e. loss of heterozygosity (LOH) and microsatellite instability (MSI) are frequent molecular events in thyroid tumour aetiopathogenesis. They were found in several chromosomal critical areas, including 3p12–p21.2, 3p24.2–p25.3, 7q21.1–q31.2, 10q22–24, and 15q11–q13, with loci of oncogenes and tumour suppressor genes.Aim of the study: Evaluation of usefulness of LOH/MSI as diagnostic/prognostic biomarker ...

The search for new differentiating biomarkers in follicular-cell derived thyroid tumors (FCDT), especially for the FNAB with underdetermined cytology, is an important scientific task. Disturbed expression of tumor suppressor genes plays important role in thyroid carcinogenesis. In this study we focused on epigenetic mechanism influencing on trefoil factor 3 (TFF3) and tissue inhibitor of metalloproteinases 3 (TIMP3) expression.Aim of the study: Evaluatio...